Analysis of Shear-Induced Platelet Aggregation and Breakup
نویسندگان
چکیده
منابع مشابه
Ligustrazine, allicin and shear-induced platelet aggregation.
Blood flow interacts with blood constituents and blood vessel under shear stress. Shear-induced platelet aggregation (SIPA) under high shear stress of stenosis has attracted research attention due to its involvement in vascular diseases, especially in life-threatening thrombosis. In SIPA, the calcium channel of platelet membrane can be activated by the interaction between plasma vWF and membran...
متن کاملShear-induced platelet aggregation in cerebral ischemia.
BACKGROUND AND PURPOSE Recent evidence has suggested that shear-induced platelet aggregation is an important mechanism of thrombosis at arterial bifurcations or stenoses. We measured shear-induced platelet aggregation with a new apparatus in patients with cerebral ischemia and also studied correlations with other hemostatic parameters as well as the effect of antiplatelet agents. METHODS The ...
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A cone and plate viscometer and Coulter Counter were used to study platelet modulation of polymorphonuclear leukocyte (PMNL) aggregation caused by controlled shear stress. As an index of aggregation, the large-particle percentage (LPP) was calculated. This represents the ratio of aggregated cell count to total cell count. PMNL suspensions in buffer (1 .0 x iO cells per milliliter. final concent...
متن کاملPlatelet modulation of polymorphonuclear leukocyte shear induced aggregation.
A cone and plate viscometer and Coulter Counter were used to study platelet modulation of polymorphonuclear leukocyte (PMNL) aggregation caused by controlled shear stress. As an index of aggregation, the large-particle percentage (LPP) was calculated. This represents the ratio of aggregated cell count to total cell count. PMNL suspensions in buffer (1.0 X 10(7) cells per milliliter, final conce...
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BACKGROUND Refrigeration of platelets (PLTs) offers an attractive alternative to the currently practiced storage at room temperature since it may mitigate problems associated with bacterial contamination and extend storage lifetime. Refrigeration causes a number of biophysical and biochemical changes in PLTs and decreases PLT circulation time in vivo. However, the effect of refrigeration on PLT...
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ژورنال
عنوان ژورنال: Annals of Biomedical Engineering
سال: 2015
ISSN: 0090-6964,1573-9686
DOI: 10.1007/s10439-015-1409-1